PELATIHAN FISIK SEDANG MENINGKATKAN KADAR VASCULAR ENDOTHELIAL GROWTH FACTOR DAN STROMAL CELL-DERIVED FACTOR-1 SERUM

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Anak Agung Ayu Putri Permatasari
I Wayan Rosiana
I Gede Widhiantara
Chela Krisna Denata
Ferbian Milas Siswanto

Abstract

Pelatihan fisik mempengaruhi berbagai sistem dalam tubuh yang berperan mempertahankan kebugaran fisik dan memperlambat proses penuaan. Penelitian menunjukkan bahwa kadar vascular endothelial growth factor (VEGF) dan stromal cell-derived factor-1 (SDF-1) menurun seiring dengan penuaan. Penelitian ini bertujuan membuktikan bahwa pelatihan fisik sedang meningkatkan kadar VEGF dan SDF-1 sebagai salah satu mekanisme penghambat proses penuaan. Penelitian ini menggunakan randomized pre-post test control group design dengan menggunakan 24 ekor tikus wistar (Rattus norvegicus) jantan sehat dengan umur 2,5 - 3 bulan, berat badan 180 -200 g yang dibagi dalam dua kelompok (n= 12 ekor). Kelompok kontrol tidak diberikan perlakuan atau sedentary lifestyle (P0) dan kelompok perlakuan diberi pelatihan fisik sedang selama 4 minggu (P1).  Kadar VEGF dan SDF-1 diperiksa menggunakan ELISA. Hasil penelitian menunjukkan bahwa pelatihan fisik sedang meningkatkan kadar VEGF (43,88±6,24 menjadi 69,80 ± 10,04 pg mL-1; p<0,001) dan SDF-1 (1,82 ± 0,17 to 3,81±0,39 ng mL-1; p< 0,001). Hasil penelitian ini menunjukkan kemungkinan VEGF dan SDF-1 sebagai mediator efek yang memperlambat penuaan. Namun, perlu dilakukan penelitian lebih lanjut untuk mengidentifikasi korelasi antara peningkatan kadar VEGF dan SDF-1 dengan fenotip penuaan.

Article Details

How to Cite
Anak Agung Ayu Putri Permatasari, I Wayan Rosiana, I Gede Widhiantara, Chela Krisna Denata, & Ferbian Milas Siswanto. (2021). PELATIHAN FISIK SEDANG MENINGKATKAN KADAR VASCULAR ENDOTHELIAL GROWTH FACTOR DAN STROMAL CELL-DERIVED FACTOR-1 SERUM. Jurnal Bioteknologi Dan Biosains Indonesia, 7(2), 226–233. https://doi.org/10.29122/jbbi.v7i2.3228
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