CONCOMITANT PSORIASIS VULGARIS AND METABOLIC SYNDROME: A CASE REPORT

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Qanita Khairunnisa

Abstract

Among the various dermatological conditions, psoriasis assumes significant relevance concerning Metabolic Syndrome (MetS). A 57-year-old man presents with pruritic and scaly erythematous plaque on the right ankle persisting for four weeks. The dermatological examination uncovered a noticeable erythematous plaque with a scaly surface on the right ankle, conclusively observed as psoriasis clinical features. Physical examination for metabolic syndrome indicated blood pressure readings of 160/100 mmHg and central obesity with a waist circumference of 98 cm. The psoriasis treatment involves the use of topical corticosteroids and emollients, along with oral metabolic medication consisting of simvastatin and amlodipine, and lifestyle modifications to treat the metabolic disorder. Metabolic syndrome leads to an elevation in the synthesis of pro-inflammatory cytokines, which are shared characteristics with psoriasis. Following comprehensive therapy of ten days of topical treatment and lifestyle modifications, the patient experienced an improvement in the active psoriatic lesions, despite the presence of metabolic disorders.

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How to Cite
Khairunnisa, Q. (2024). CONCOMITANT PSORIASIS VULGARIS AND METABOLIC SYNDROME: A CASE REPORT. Jurnal Bioteknologi Dan Biosains Indonesia, 11(2), 412–417. Retrieved from https://ejournal.brin.go.id/JBBI/article/view/5571
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References

Ali N, Kuruvila M, Unnikrishnan B (2014) Psoriasis and metabolic syndrome: A case control study. Indian J Derma-tology, Venereol Leprol 80:255-257. doi: 10.4103/0378-6323.132257

Asad F, Rizvi F, Azhar A (2019) Remarka-ble effect of topical betamethasone valerate 0.1% on progress of psoriasis disease. Prof Med J 26:1542-1545. doi: 10.29309/TPMJ/2019.26.09.4020

Debbaneh M, Millsop JW, Bhatia BK, Koo J, Liao W (2014) Diet and psoriasis, part I: Impact of weight loss interven-tions. J Am Acad Dermatol 71:133-140. doi: 10.1016/j.jaad.2014.02.012

Drvar DL, Vlahinić T, Maleš Ž, Turčić P, Čeović R (2019) A modern approach to the treatment of plaque psoriasis. Acta Pharm 69:511-523. doi: 10.2478/acph-2019-0047

Ferdinando LB, Fukumoto PK, Sanches S, Fabricio LHZ, Skare TL (2018) Meta-bolic syndrome and psoriasis: A study in 97 patients. Rev Assoc Med Bras 64:368-373. doi: 10.1590/1806-9282.64.04.368

Fernández‐Armenteros JM, Gómez‐Arbonés X, Buti‐Soler M, Betriu-Bars A, Sanmartin-Novell V, Ortega-Bravo M, Martínez-Alonso M, Garí E, Por-tero-Otín M, Santamaria-Babi L, Cas-anova-Seuma JM (2019) Psoriasis, metabolic syndrome and cardiovas-cular risk factors. A population‐based study. J Eur Acad Dermatology Vene-reol 33:128-135. doi: 10.1111/jdv.15159

Ford ES (2005) Prevalence of the metabol-ic syndrome defined by the interna-tional diabetes federation among adults in the U.S. Diabetes Care 28:2745-2749. doi: 10.2337/diacare.28.11.2745

Gisondi P, Fostini AC, Fossà I, Girolomoni G, Targher G (2018) Psoriasis and the metabolic syndrome. Clin Dermatol 36:21-28. doi: 10.1016/j.clindermatol.2017.09.005

Gui X, Yu X, Jin H, Zuo Y, Wu C (2018) Prevalence of metabolic syndrome in Chinese psoriasis patients: A hospital‐based cross‐sectional study. J Diabe-tes Investig 9:39-43. doi: 10.1111/jdi.12663

Hao Y, Zhu Y, Zou S, Zhou P, Hu Y, Zhao Q, Gu L, Zhang H, Wang Z, Li J (2021) Metabolic syndrome and pso-riasis: Mechanisms and future direc-tions. Front Immunol 12:711060. doi: 10.3389/fimmu.2021.711060

Jensen P, Skov L (2016) Psoriasis and obesity. Dermatology 232:633-639. doi: 10.1159/000455840

Kim H-N, Han K, Park Y-G, Lee JH (2019) Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study. Metabolism 99:19-24. doi: 10.1016/j.metabol.2019.07.001

Lee H-J, Kim M (2023) Challenges and fu-ture trends in the treatment of psoria-sis. Int J Mol Sci 24:13313. doi: 10.3390/ijms241713313

Lønnberg AS, Skov L, Skytthe A, Kyvik KO, Pedersen OB, Thomsen SF (2016) Smoking and risk for psoriasis: a population‐based twin study. Int J Dermatol 55:e72-e78. doi: 10.1111/ijd.13073

Maroto-Morales D, Montero-Vilchez T, Ari-as-Santiago S (2021) Study of skin barrier function in psoriasis: The im-pact of emollients. Life 11:651. doi: 10.3390/life11070651

Mattei PL, Corey KC, Kimball AB (2014) Psoriasis area severity index (PASI) and the dermatology life quality index (DLQI): The correlation between dis-ease severity and psychological bur-den in patients treated with biological therapies. J Eur Acad Dermatology Venereol 28:333-337. doi: 10.1111/jdv.12106

Merola JF, Kavanaugh A, Lebwohl MG, Gniadecki R, Wu JJ (2022) Clinical efficacy and safety of psoriasis treatments in patients with concomi-tant metabolic syndrome: A narrative review. Dermatol Ther (Heidelb) 12:2201-2216. doi: 10.1007/s13555-022-00790-2

Pannu S, Rosmarin D (2021) Psoriasis in patients with metabolic syndrome or type 2 diabetes mellitus: Treatment challenges. Am J Clin Dermatol 22:293-300. doi: 10.1007/s40257-021-00590-y

Peralta C, Hamid P, Batool H, Al Achkar Z, Maximus P (2019) Psoriasis and met-abolic syndrome: Comorbidities and environmental and therapeutic impli-cations. Cureus 11:e6369. doi: 10.7759/cureus.6369

Prasad DS, Kabir Z, Revathi Devi K, Peter PS, Das BC (2020) Gender differ-ences in central obesity: Implications for cardiometabolic health in South Asians. Indian Heart J 72:202-204. doi: 10.1016/j.ihj.2020.04.008

Segaert S, Calzavara-Pinton P, de la Cue-va P, Jalili A, Lons Danic D, Pink AE, Thaçi D, Gooderham M (2022) Long-term topical management of psoriasis: The road ahead. J Dermatolog Treat 33:111-120. doi: 10.1080/09546634.2020.1729335

Singh S, Young P, Armstrong AW (2017) An update on psoriasis and metabolic syndrome: A meta-analysis of obser-vational studies. PLoS One 12:e0181039. doi: 10.1371/journal.pone.0181039

Socha M, Pietrzak A, Grywalska E, Pie-trzak D, Matosiuk D, Kiciński P, Ro-linski J (2020) The effect of statins on psoriasis severity: a meta-analysis of randomized clinical trials. Arch Med Sci 16:1-7. doi: 10.5114/aoms.2019.90343

Stefanadi EC, Dimitrakakis G, Antoniou C-K, Challoumas D, Punjabi N, Dimi-trakaki IA, Punjabi S, Stefanadis CI (2018) Metabolic syndrome and the skin: a more than superficial associa-tion. Reviewing the association be-tween skin diseases and metabolic syndrome and a clinical decision algo-rithm for high risk patients. Diabetol Metab Syndr 10:9. doi: 10.1186/s13098-018-0311-z

Voiculescu VM, Lupu M, Papagheorghe L, Giurcaneanu C, Micu E (2014) Psori-asis and metabolic syndrome--scientific evidence and therapeutic implications. J Med Life 7:468-471.

Wu JJ, Kavanaugh A, Lebwohl MG, Gni-adecki R, Merola JF (2022) Psoriasis and metabolic syndrome: Implications for the management and treatment of psoriasis. J Eur Acad Dermatology Venereol 36:797-806. doi: 10.1111/jdv.18044

Yuwita W, Gunawan H, Sugiri U, Sandiono D (2017) Metabolic Syndrome in pso-riasis vulgaris patient: A case report. Berkala Ilmu Kesehatan Kulit dan Ke-lamin 28:251-255.