SINTESIS DAN KARAKTERISASI MEMBRAN KOMPOSIT KITOSANHIDROKSI APATIT BERIKATAN SILANG SEBAGAI GUIDED TISSUE REGENERATION (GTR)[Synthesis and Characterization of the Chitosan (Cs)-Hydroxyapatite (Ha) Crosslinked Composite Membrane for Guided Tissue Regeneration (GTR)]

Abstract

In the preparation of biomaterials to be useful for guided tissue regeneration (GTR), the chitosan (CS)- hydroxyapatite (HA) crosslinked membrane has been synthesized and characterization its physico-chemical. HA with varying weight ( 2- 6 g) was mixed with 4% CS solution and processed to composite membrane, and then crosslinking with sodium sulfite (Na2SO3). Chemical structure and morphology of membranes were characterized using Fourier Transform Infra Red spectrophotometer (FTIR) and Scanning Electron Microscope (SEM) The results showed that the membrane capable to absorb water relatively fast (5 min) and stable with the increase of time. With increasing of HA content, the biodegradation of membranes increase. In contrast, the tensile strength and elongation at break of membranes decrease. FTIR spectra showed a crosslinking CS-HA membrane. The CS-HA composite membrane could be considered to be used as GTR (Guided Tissue Regeneration ) membrane in periodontal.