PEMBUATAN KOMPOSIT POLIKAPROLAKTON-KITOSAN-HIDROKSIAPATIT IRADIASI UNTUK APLIKASI BIOMATERIAL[Preparation of Irradiated Polycaprolactone-Chitosan-Hydroxyapatite for Biomaterial Application]

Abstract

Biocompatible polycaprolactone-chitosan-hydroxyapatite composite with various composition were prepared using glacial acetic acid solvent and film casting method at room temperature. Irradiation process was done using electron beam machine at the dose of 10-50 kGy. These membranes were investigated for its ability to absorp water, mechanical properties, identification of functional group with fourier transform infra red spectroscopy (FTIR) and diffraction pattern analysis with x-ray diffraction (XRD). Water absorption increased with the increasing of chitosan and hydroxyapatite because of their hidrophilicity. Mechanical properties test shows the increased of tensile strength and decreased of elongation as the irradiation dose rises. FTIR absorbed bands composite membrane I to IV shows association of specific peaks of polycaprolactone, chitosan and hydroxyapatite. Diffraction pattern analysis by using XRD shows unchanged of crystal structures in composite membranes. The results of this study show the composition of membranes is prospective for the further development of biomaterial for clinical application.