OPTIMASI PH ALUMINA DAN 99Mo DALAM PEMBUATAN GENERATOR 99Mo/99mTc BERBASIS MoO3 ALAM

Abstract

Alumina material has long been used for ⁹⁹Mo radioisotope adsorbent in the ⁹⁹Mo/^99mTc generator. The ⁹⁹Mo/^99mTc generator produces ^99mTc radioisotope which is used for the diagnostic purposein nuclear medicine. To date, alumina is used to adsorp ⁹⁹Mo obtained from fission reaction of ²³⁵U. The restriction of the use of fission ²³⁵U leads to the find of an alternative ⁹⁹Mo. The alternative of ⁹⁹Mo production is obtained from natural MoO₃ which is irradiated by thermal neutron in the nuclear reactor. The ⁹⁹Mo radioisotope produced from this reaction has no carrier-free properties. This is due to the abundanceof natural MoO₃ is 24.13%.In the⁹⁹Mo/^99mTc generator based on natural MoO₃ by using alumina column, it is necessary to know the alumina type for optimum ⁹⁹Mo adsorption, as well as pH of ⁹⁹Mo. In this study, there were used three variations of alumina-based generator column namely acid, neutral, and basic alumina. The ⁹⁹Mo solution used in this study was also performed three pH: pH 4, pH 7, and pH 8 of the ⁹⁹Mo solution. The generator eluted and observed daily for 3 days and continued after the next two days for 2 days. The optimum adsorption of ⁹⁹Mo from natural MoO₃  by alumina material was given in the use of acidic alumina with the pH 4 of the⁹⁹Mo solution. Among the three pH variation of the ⁹⁹Mo solution, the ⁹⁹Mo solution of pH 4 gives the highest of ^99mTc yield. The column with the smallest ⁹⁹Mo breakthrough is given by acidic alumina column using the ⁹⁹Mo solution of pH 4. Thus, acidic alumina column can be used as an adsorbent to adsorp natural ⁹⁹Mo.