PENGARUH REGENERASI KOLOM ALUMINA ASAM TERHADAP RECOVERY DAN KUALITAS 99mTc HASIL EKSTRAKSI PELARUT MEK DARI 99Mo HASIL AKTIVASI NEUTRON

Abstract

Purification of ^99mTc from ⁹⁹Mo activation using acidic alumina column chromatography system from MEK (Methyl Ethyl Keton) extraction has been carried out through cooperation between PTRR - BATAN, Chiyoda and JAEA Japan. This method has a limitation that acidic alumina column for purification of ^99mTc can be used only once, for the next purification acidic alumina column should be replaced with new column, so it is less practical and also requires high cost. This study aims to obtain a ^99mTc solution can be used for labelling of a radiopharmaceutical kit. In this study, the used of acidic alumina column for ^99mTc purification was tried more than once by regeneration using 0.1N HNO₃ solution after purification process is completed. Parameters observed in this study are the percent recovery, elution profile, pH, radiochemical purity and radionuclide purity. The results of observational studies conducted over 5 days has been obtained pH ~ 5, % recovery > 60%, radiochemical purity of > 95% and ⁹⁹Mo leakage not detected. The treatment of acidic alumina column with 0,1 N HNO₃ solution concluded that acidic alumina column does not need to be replaced every day.