OPTIMASI PENGGUNAAN HCl SEBAGAI LARUTAN PENGELUSI ITRIUM-90 DALAM DOWEX® 50WX8-200

Abstract

OPTIMIZATION OF USE HCl AS SOLUTION FOR ELUTION ITRIUM-90 IN DOWEX^® 50WX8- 200. Yttrium-90 is a β emitter radionuclide with a half life of 64.1 hours and emits the maximum β energy at 2280 keV. Yttrium-90 radionuclide is widely used in nuclear medicine for therapeutic purposes. ⁹⁰Sr/⁹⁰Y generator system has been developed to obtain carrier-free ⁹⁰Y. Yttrium-90 were obtained from the ⁹⁰Sr/⁹⁰Y generator in the form of ⁹⁰Y-citrate radiochemical. The ⁹⁰Y ideal for tagging ligands is in the form of ⁹⁰YCl₃. To obtain the desired radiochemical a series of processes with ion exchange resin method is performed using Dowex^® 50WX8-200. In this study optimization of the use of HCl for has been carried out ⁹⁰Y elution from the resin with varied HCl concentration and contact time when ⁹⁰Y is eluted from the resin. The release of ⁹⁰Y from resin Dowex® 50WX8-200 depending on the concentration of HCl is used. The greater the concentration of HCl release rate of ⁹⁰Y from ⁹⁰Y-Dowex greater. The optimum contact time with 5 mL of 12 N HCl is 60 minutes with a result of 9.4%. The ⁹⁰Y test results after eluted from Dowex® 50WX8-200 indicated that the ⁹⁰Y was in the form of ⁹⁰YCl_3.