TINJAUAN LOVASTATIN DAN APLIKASINYA
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Abstract
Lovastatin merupakan obat golongan statin yang digunakan untuk menurunkan kadar kolesterol dalam darah. Mekanisme kerja lovastatin adalah menghambat enzim HMG-CoA reduktase sehingga produksi kolesterol di dalam hati berkurang. Beberapa kapang berfilamen memproduksi lovastatin dan Aspergillus terreus merupakan kapang penghasil lovastatin tertinggi sehingga digunakan dalam produksi lovastatin. Produksi lovastatin secara komersial menggunakan fermentasi cair tetapi sekarang ini fermentasi padat menjadi alternatif lain untuk memproduksi lovastatin. Lovastatin digunakan terutama untuk antihiperkolesterolemia. Lovastatin juga potensial digunakan untuk pengobatan penyakit alzheimer, kanker, osteoporosis, parkinson, multiple sclerosis, dan rheumatoid arthritis.
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References
Atalla MM, Hamed ER, El-Shami AR (2008) Optimization of a culture medium for increased mevinolin production by Aspergillus terreus strain. Malay J Microbiol 4:6-10
Barrios-González J, Miranda RU (2010) Biotechnological production and applications of statins. Appl Microbiol Biotechnol 85:869-883
Bizukojc M, Pawlowska B, Stanislaw L (2007) Supplementation of the cultivation media with B-group vitamins enhances lovastatin biosynthesis by Aspergillus terreus. J Biotechnol 127:258-268
Demierre M, Higgins PDR, Gruber SB, Hawk E, Lippman SM (2005) Statins and cancer prevention. Nat Rev 5:930-942
Devi SK, Rao JV, Narasu LM, Saikrishna K (2011) Isolation and screening of lovastatin producing Aspergillus terreus fungal strains from soil samples. Int J Pharm Technol 3:2772-2782
Emerton D (2006) Patent expiries in the US statin market: Generics to slash market size by 80 per cent over the next ten years. J Generic Med 4:74
Hajjaj H, Niederberger P, Duboc P (2001) Lovastatin biosynthesis by Aspergillus terreus in a chemically defined medium. Appl Environ Microbiol 67:2596-2602
Jaivel N, Marimuthu P (2010) Isolation and screening of lovastatin producing microorganisms. Int J Eng Sci Technol 2:2607-2611
Lai LT, Hung C, Lo C (2007) Effect of lactose and glucose on production of itaconic acid and lovastatin by Aspergillus terreus ATCC 20542. J Biosci Bioeng 104:9-13
Lopez JLC, Perez JAS, Sevilla JMF, Fernandez FGA, Grima EM, Chisti Y (2003) Production of lovastatin by Aspergillus terreus: effect of the C:N ratio and the principal nutrients on growth and metabolite production. Enzyme Microbiol Tehnol 33:270 -277
Lopez JLC, Perez JAS, Sevilla JMF, Fernandez FGA, Grima EM, Chisti Y (2004) Fermentation optimization for the production of lovastatin by Aspergillus terreus: use of response surface methodology. J Chem Biotechnol 79:1119-1126
Lopez JLC, Perez JAS, Sevilla JMF, Fernandez FGA, Grima EM, Chisti Y (2005) Pellet morphology, culture rheology and lovastatin production in cultures of Aspergillus terreus. J Biotechnol 116:61-77
Manzoni M, Rollini M (2002) Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl Microbiol Biotechnol 58:555-564
Osman ME, Khattab OH, Zaghlol GM, Abd El-Hameed RM (2011) Screening for the production of cholesterol lowering drugs (lovastatin) by some fungi. Aust J Basic Appl Sci 5:698-703
Porcel EMR, Lopez JLC, Ferron MAV, Perez JAS, Sanchez JLG, Chisti Y (2006) Effects of the sporulation conditions on the lovastatin production by Aspergillus terreus. Bioprocess Biosynt Eng 29:1-5
Porcel EMR, Lopez JLC, Perez JAS, Chisti Y (2008) Lovastatin production by Aspergillus terreus in a two-staged feeding operation. J Chem Technol Biotechnol 83:1236-1243
Samiee SM, Moazami N, Haghighi S, Mohseni FA, Mirdamadi S, Bakhtiari MR (2003) Screening of lovastatin production by filamentous fungi. Iranian Biom J 7:29-33
Seenivasan A, Subhagar S, Aravindan R, Viruthagiri T (2008) Microbial production and biomedical applications of Lovastatin. Indian J Pharm Sci 70:701
Shindia AA (2001) Some nutritional factors influencing mevinolin production by Aspergillus terreuss strain. Folia Microbiol 46:413-416
Szakacs G, Morovjan G, Tengerdy RP (1998) Production of lovastatin by a wild starin of Aspergillus terreus. Biotechnol Lett 20:411-415
Tobert JA (2003) Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discovery 2:517-526