ANTIFUNGAL ACTIVITY OF N-HEXANE EXTRACT FROM Chaetoceros calcitrans AGAINST Candida sp.

Main Article Content

Firdha Rachmawati
Patricia Gita Naully
Prina Puspa Kania
Delia Ayu Pasha

Abstract

Skin infections caused by Candida albicans and Candida krusei pose a serious health issue. One major concern regarding these infections is the resistance to antifungal drugs, highlighting the need for natural antifungals. Chaetoceros calcitrans, a microalgae, is known to contain natural antimicrobial compounds. This study aims to evaluate the antifungal potential of C. calcitrans n-hexane extract against both pathogens. The antifungal activity was tested using the diffusion method. The results indicated that the extract at a concentration of 100 mg mL⁻¹ inhibited the growth of C. albicans and C. krusei, showing the highest inhibition zones of 10.3 ± 0.9 mm and 9 ± 1.4 mm, respectively. GC-MS analysis revealed that the C. calcitrans extract contains antifungal compounds, including 2-Butyl-1-hexyloctahydro-1H-indene, at a concentration of 30.72%. Therefore, it can be concluded that C. calcitrans extract possesses antifungal activity and has potential as a drug candidate for fungal skin infections.

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How to Cite
Rachmawati, F., Naully, P. G., Kania, P. P., & Pasha, D. A. (2024). ANTIFUNGAL ACTIVITY OF N-HEXANE EXTRACT FROM Chaetoceros calcitrans AGAINST Candida sp. Jurnal Bioteknologi Dan Biosains Indonesia, 11(1), 145–154. Retrieved from https://ejournal.brin.go.id/JBBI/article/view/6202
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