THE ADVANCED ELECTRIC FIELD FROM QUAD-ELECTRODE MODE FOR BLOOD CANCER TRAPPING: SIMULATION STUDY
Keywords:
Blood Cancer, Filtering, Electric Field, Good Health, DielectrophoresisAbstract
THE ADVANCED ELECTRIC FIELD FROM QUAD-ELECTRODE MODE FOR BLOOD CANCER TRAPPING: SIMULATION STUDY. Blood cancer is a disease caused by the rapid cleavage of white blood cells (WBC), which increases in the human circulatory system. Furthermore, based on the original nature of WBC during cleavage, which is the same as ionic bonds, electric field filtering, and trapping is used to treat leukemia patients. The electric field generated by the electrode with an AC voltage source plays a role in the migration of the WBC to high electric field intensity. The Quad-electrode field distribution is conducted using the Finite Element Method (FEM), and an electric field gradient analysis is conducted to determine the effectiveness of each coordinate system. According to the simulation results, the second model with an input voltage of 0.68 V has the highest intensity of electric field distribution, with an effective depth at Z = 30 mm, and the best coordinate along the X-axis and Y-axis are 30 mm. In conclusion, the center of the Quad-electrode system center is the best location for placing filters and trapping leukocytes by utilizing electric field distribution on the electrode system for the development of blood cancer biomedical therapy technology.
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References
N. C. Institute, “Cancer Stat Facts: Leukemia”, National Cancer Institute, 2021.
D. Rodriguez-Abreu, A. Bordoni, and E. Zucca, “Epidemiology of hematological malignancies”, Annals of
Oncology, vol. 18, no. SUPPL. 1, pp. 13–18, 2007.
A. M. and A. M. Janjua H U, Naeem K, “Rouleaux formation of white blood cells and platelets in leukemia”,
Bioscience Journal, vol. 34, no. 2, pp. 1010–20, 2018.
T. A. Crowley and V. Pizziconi, “Isolation of plasma from whole blood using planar microfilters for lab-on-a-chip
applications”, Lab on a Chip, vol. 5, no. 9, pp. 922–929, 2005.
H. M. Ji, V. Samper, Y. Chen, C. K. Heng, T. M. Lim, and L. Yobas, “Silicon-based microfilters for whole blood
cell separation”, Biomedical Microdevices, vol. 10, no. 2, pp. 251–257, 2008.
S. Ferdowsi, Z. Abbasi-Malati, and A. A. Pourfathollah, “Leukocyte reduction filters as an alternative source of
peripheral blood leukocytes for research”, Hematology, Transfusion and Cell Therapy, no. x x, pp. 0–4, 2021.
K. Sriprawat et al., “Effective and cheap removal of leukocytes and platelets from plasmodium vivax infected
blood”, Malaria Journal, vol. 8, no. 1, pp. 1–7, 2009.
S. Larsson, H. Gulliksson, and D. Paunovic, “Evaluation of a whole-blood WBC-reduction filter that saves platelets:
In vitro studies”, Transfusion, vol. 41, no. 4, pp. 534–539, 2001.
V. Fahradyan et al., “Leukoreduction in ex vivo perfusion circuits: comparison of leukocyte depletion efficiency
with leukocyte filters”, Perfusion (United Kingdom), vol. 35, no. 8, pp. 853–860, 2020.
G. Rozenberg, Microscopic 3e Heamotology a Practical guide for the laboratory. 2011.
O. Z. Siani, M. Sojoodi, M. Z. Targhi, and M. Movahedin, “Blood particle separation using dielectrophoresis in a
novel microchannel: A numerical study”, Cell Journal, vol. 22, no. 2, pp. 218–226, 2019.
C. Szydzik, K. Khoshmanesh, A. Mitchell, and C. Karnutsch, “Microfluidic platform for separation and extraction
of plasma from whole blood using dielectrophoresis”, Biomicrofluidics, vol. 9, no. 6, pp. 1–16, 2015.
I. Doh and Y. H. Cho, “A continuous cell separation chip using hydrodynamic dielectrophoresis (DEP) process”,
Sensors and Actuators, A: Physical, vol. 121, no. 1, pp. 59–65, 2005.
M. Jahangiri et al., “Low frequency stimulation induces polarization-based capturing of normal, cancerous and white
blood cells: A new separation method for circulating tumor cell enrichment or phenotypic cell sorting”, Analyst, vol.
, no. 23, pp. 7636–7645, 2020.
D. W. Lee and Y. H. Cho, “A continuous electrical cell lysis device using a low dc voltage for a cell transport and
rupture”, Sensors and Actuators, B: Chemical, vol. 124, no. 1, pp. 84–89, 2007.
C. Kremer, C. Witte, S. L. Neale, J. Reboud, M. P. Barrett, and J. M. Cooper, “Shape-dependent optoelectronic cell
lysis”, Angewandte Chemie - International Edition, vol. 53, no. 3, pp. 842–846, 2014.
Y. Palti, “Method for Selectively Destroying Dividing Cells”, U.S. Patent Application No, 11/470,405, 2007.
C. Polk, “Therapeutic applications of low-frequency sinusoidal and pulsed electric and magnetic fields”, in Bronzino
J D, editor The biomedical engineering handbook., 1995, pp. 1404–16.
C. A. L. Bassett, “The development and application of pulsed electromagnetic fields (PEMFs) for ununited fractures
and arthrodeses”, Clin Plast Surg, vol. 12, no. 2, pp. 259–77, 1985.
E. Elson, “Biologic effects of radiofrequency and microwave fields: in vivo and in vitro experimental results.”, in
In: Bronzino JD, editor. The biomedical engineering handbook, 1995, pp. 1417–23.
E. D. Kirson, R. S. Schneiderman, V. Dbaly, F. Tovarys, J. Vymazal, A. Itzhaki, M. Daniel, G. Zoya, S. Esther, G.
Dorit, W. Yoram W, and Y. Palti, “Chemotherapeutic Treatment Efficacy and Sensitivity are Increased by Adjuvant
Alternating Electric Fields (TTFields)”, BMC Med.Phys, vol. 9, no. 1, pp. 1–13, 2009.
S. Takashima and H. P. Schwan, “Alignment of microscopic particles in electric fields and it’s biological
implications”, Biophys J, vol. 47, no. 4, pp. 513–518, 1985.
Y. Huang and R. Pethlg, “Electrode design for negative dielectrophoresis”, Measurement Science and Technology,
vol. 2, no. 12, pp. 1142–1146, 1991.
A. R. and N. N. Miftakhul Firdhaus, Ulya Farahdina, Vinda Zakiyatuz Zulfa, Endarko, “Electric Field Distribution
Analysis of Blood Cancer as a Potentially Blood Cancer Therapy”, 2021.
IFAC, “Calculation of the Dielectric Properties of Body Tissues in the frequency range 10 Hz - 100 GHz”, Italian
National Research Council, 2021.
A. Surowiec, S. S. Stuchly, and C. Izaguirre, “Dielectric properties of human B and T lymphocytes at frequencies
from 20 kHz to 100 MHz”, Physics in Medicine and Biology, vol. 31, no. 1, pp. 43–53, 1986.
G. A. Justin, Y. Zhang, X. T. Cui, C. W. Bradberry, M. Sun, and R. J. Sclabassi, “A Metabolic Biofuel Cell:
Conversion of Human Leukocyte Metabolic Activity to Electrical Currents”, Journal of Biological Engineering,
vol. 5, no. 1, p. 5, 2011.
B. A. Markx, L. Carney, M. Littlefair, and A. Sebastian, “Recreating the hematon Microfabrication of artificial
haematopoietic stem cell micronichesin vitrousing dielectrophoresis”, Biomed Microdevices, vol. 11, no. 1, pp. 143–
, 2009.
D. S. Gray, J. L. Tan, J. Voldman, and C. S. Chen, “Dielectrophoretic registration of living cells to a microelectrode
array”, Biosens Bioelectron, vol. 19, no. 12, pp. 1765–1774, 2004.
M. Schueller, A. Blaszczyk, F. Mauseth, H. K. Meyer, N. Stieger, and J. Smajic, “Charge Accumulation on Slightly
Conductive Barrier Systems and Its Effect on Breakdown Voltage in an Air Insulated Rod Plane”, in Arrangement
Proceedings of the 21st International Symposium on High Voltage Engineering, 2020, pp. 1155–1165.
A. B. and H. M. Hazlee I, Mohsin AT, “Distribution of electric field in capacitor and surge arrester bushings”, IEEE
International Conference on Power and Energy (PECon), pp. 973–978, 2012.
P. S, The Concise Human Body book. 2019.
T. B. Jones and T. B. Jones, “Electromechanics of particles”, in Cambridge University Press, 2005, 26, pp. 1780-
J. Yang, Y. Huang, X. Wang, X. B. Wang, F. F. Becker, and P. R. Gascoyne, “Dielectric Properties of Human
Leukocyte Subpopulations Determined by Electrorotation as a Cell Separation Criterion”, Biophysical Journal, vol.
, no. 6, pp. 3307–3314, 1999.
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