MORPHOLOGY AND TENSILE PROPERTIES OF PVA/SNAIL MUCIN NANOFIBER MEMBRANES
DOI:
https://doi.org/10.17146/jsmi.2018.19.4.4966Keywords:
Electrospinning, Nanofibers, Snail mucin, PVA, Wound dressingAbstract
MORPHOLOGY AND TENSILE PROPERTIES OF PVA/SNAIL MUCIN NANOFIBER MEMBRANES. Snail mucin has been widely known to contain agents with wound healing properties. A preliminary research with regard to the potential to manufacture composite nanofibrous membranes of polyvinyl alcohol (PVA) and snail mucin (SM) by the electrospinning technique for wound dressing applications has been conducted. The effect of SM concentration on the morphology and tensile properties of PVA/SM nano membrane has been investigated. The PVA/SM solutions with various concentration of SM (0%, 2%, 4%, dan 6%)(w/v) were electrospun at the optimized process parameters. The morphology nanofiber membranes was observed by scanning electron microscopy and the average diameters of prepared nanofibers was determined by image analysis technique. The tensile test was conducted to examine the tensile properties of the nanofiber membranes being prepared according to ASTM D882. The PVA/SM nanofibre membrane possessing the tensile strength and tensile strain ranging between 3.48-5.37 MPa and 101.25- 157.13 %, respectively were successfully fabricated. The membrane of 10% (w/v) PVA/ 2% (w/v) SM achieved the highest values of tensile strength. This phenomenon has been associated to the uniformity of fiber size diameter distribution within the membranes. It was expected that further optimization of the processing would allow development of the tensile properties compatibility requirement with this being the subject of future work by the authors.
Downloads
References
M. Abrigo, McArthur SL and Kingshott P. “Electrospun Nanofibers as Dressings for Chronic Wound Care: Advances, Challenges, and Future Prospects”. Macromolecular Bioscience, vol. 14, pp. 772-792, 2014.
K. A. Rieger, Nathan P. Bircha and Jessica D. Schiffman. “Designing Electrospun Nanofiber Mats to Promote Wound Healing – a Review”. Journal of Materials Chemistry B, vol. 1, pp. 4531-4541, 2013.
M. Koosha and H. Mirzadeh. “Electrospinning, Mechanical Properties, and Cell Behavior Study of Chitosan/PVA Nanofibers”. Journal of Biomedical Materials Research Part A, vol. 103, pp. 3081-3093, 2015.
M. Gizaw, Thompson J, Faglie A, Lee SY, Neuenschwander P and Chou SF. “Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications”. Bioengineering, vol. 5, pp. 9, 2018.
M. Wang, A.K. Roy, and T. J. Webster. “Development of Chitosan/Poly(Vinyl Alcohol) Electrospun Nanofibers for Infection Related Wound Healing”. Frontiers in Physiology, vol. 7, 2017.
C.-H. Yao, JY. Yeh, YS. Chen, MH. Li and CH. Huang. “Wound-healing Effect of Electrospun Gelatin Nanofibres Containing Centella Asiatica Extract in a Rat Model”. Journal of Tissue Engineering and Regenerative Medicine, vol. 11, pp. 905-915, 2017.
A. M. Abdelgawad, et al. “Antimicrobial Wound Dressing Nanofiber Mats from Multicomponent (Chitosan/ Ag-NPs/ Polyvinyl Alcohol) Systems”. Carbohydrate Polymers, vol. 100, pp. 166-178, 2014.
L. B. Etim, C. Aleruchi and G. A. Obande. “Antibacterial Properties of Snail Mucus on Bacteria Isolated from Patients with Wound Infection”. British Microbiology Research Journal, vol. 11, pp. 1-9, 2016.
A. S. Harti, S. D. Sulisetyawati, A. Murharyati, M. Oktariani and I. B. Wijayanti. “The Effectiveness of Snail Slime and Chitosan in Wound Healing”. International Journal of Pharma Medicine and Biological Sciences, vol. 5, pp. 76, 2016.
D. K. P. Meilanny, Pranjono and D. Hikmawati. “Electrospining Methode to Synthesize Composite based on Alginate-Polyvinyl Alcohol with Addition of Snail (Achatina Fulica)”. Proceeding on the Scientific Meeting and Presentation on Accelerator Technology and Its Applications, 2015.
D.-N. Yu, D. Tian and J. H. He. “Snail-Based Nanofibers”. Materials Letters, vol. 220, pp. 5-7, 2018.
A. J. Hassiba, M. E. El Zowalaty, G. K. Nasrallah, T. J. Webster, A. S. Luyt, A. M. Abdullah, A. A. Elzatahry. “Review of Recent Research on Biomedical Applications of Electrospun Polymer Nanofibers for Improved Wound Healing”. Nanomedicine, vol. 11, pp. 715-737, 2016.
V. Leung, R. Hartwell, H. Yang, A. Ghahary and F. Ko. “Bioactive Nanofibres for Wound Healing Applications”. Journal of Fiber Bioengineering and Informatics, vol. 4, pp. 1-14, 2011.
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.





