Dose Analysis of Esophageal Cancer Therapy with Boron Neutron Capture Therapy (BNCT) Using PHITS Version 3.33
DOI:
https://doi.org/10.55981/tdm.2025.7160Abstract
Based on statistics from the World Health Organization (WHO) in 2022, esophageal cancer ranks 7th out of 15 types of cancer that cause the highest number of deaths in the world. Boron Neutron Capture Therapy (BNCT) is a proven therapeutic method for treating esophageal cancer, as it delivers high doses of radiation selectively to cancer cells while minimizing damage to healthy tissue. This research was carried out to determine the dose absorbed by esophageal cancer, as well as to determine the optimum boron concentration, irradiation time, and irradiation direction to kill cancer utilizing the Particle and Heavy Ion Transport Code System (PHITS) software version 3.33. PHITS simulates BNCT therapy on esophageal cancer with the Monte Carlo method. According to the existing literature, no studies have explored esophageal cancer treatment using BNCT therapy in conjunction with Monte Carlo method simulation with PHITS. The results showed that the irradiation direction of 0° with a boron concentration of 150 µg/g produced a lower absorbed dose and was more efficient in irradiation time. The shortest irradiation time obtained was 31 minutes with a dose absorbed by the esophagus of 2.77 Gy, while the dose absorbed by the skin was 1.78 Gy.
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