Optimizing Boron Dose for Cervical Cancer Therapy Using BNCT and PHITS Simulations

Authors

  • Laili Rochimah Department of Physics, Faculty of Science, Sultan Maulana Hasanuddin State Islamic University, 42171, Banten, Indonesia
  • Subur Pramono Department of Physics, Faculty of Science, Sultan Maulana Hasanuddin State Islamic University, 42171, Banten, Indonesia
  • Beta Nur Pratiwi Department of Physics, Faculty of Science, Sultan Maulana Hasanuddin State Islamic University, 42171, Banten, Indonesia
  • Yohannes Sardjono Research Center for Safety, Metrology and Nuclear Quality Technology, Research Organization for Nuclear Energy, The National Research and Innovation Agency, Tangerang Selatan, Indonesia
  • Gede Sutrisna Wijaya Research Center for Safety, Metrology and Nuclear Quality Technology, Research Organization for Nuclear Energy, The National Research and Innovation Agency, Tangerang Selatan, Indonesia
  • Isman Mulyadi Triatmoko Research Center for Safety, Metrology and Nuclear Quality Technology, Research Organization for Nuclear Energy, The National Research and Innovation Agency, Tangerang Selatan, Indonesia
  • Nunung Nuraeni Research Center for Safety, Metrology and Nuclear Quality Technology, Research Organization for Nuclear Energy, The National Research and Innovation Agency, Tangerang Selatan, Indonesia
  • Heru Prasetio Research Center for Safety, Metrology and Nuclear Quality Technology, Research Organization for Nuclear Energy, The National Research and Innovation Agency, Tangerang Selatan, Indonesia
  • Nur Rahmah Hidayati Research Center for Safety, Metrology and Nuclear Quality Technology, Research Organization for Nuclear Energy, The National Research and Innovation Agency, Tangerang Selatan, Indonesia
  • Syarifatul Ulya Research Center for Safety, Metrology and Nuclear Quality Technology, Research Organization for Nuclear Energy, The National Research and Innovation Agency, Tangerang Selatan, Indonesia
  • Zuhdi Ismail Research Center for Safety, Metrology and Nuclear Quality Technology, Research Organization for Nuclear Energy, The National Research and Innovation Agency, Tangerang Selatan, Indonesia

DOI:

https://doi.org/10.55981/tdm.2025.7150

Keywords:

BNCT, Dosimetry, Cervical, PHITS

Abstract

Cervical cancer, with approximately 569,000 new cases annually, ranks as the fourth most prevalent malignancy among women worldwide. This high incidence rate significantly contributes to its position as one of the leading causes of cancer-related mortality worldwide. Boron Neutron Capture Therapy (BNCT), a form of radiotherapy based on the neutron capture principle, utilizes boron-10 as a targeted agent for destroying cancer cells. In this study, the geometry of cervical cancer tissue and surrounding healthy organs was simulated under neutron irradiation, using boron concentrations of 100, 120, and 140 μg/g from the left-lateral and posterior-anterior directions. This study aimed to determine the optimal boron concentration and irradiation time for effective eradication of stage IIIA cervical cancer while minimizing side effects. The Particle and Heavy Ion Transport Code System (PHITS) was employed to model particle transport and dose distribution. Simulation results indicate that the total dose rate required for tumor eradication in the 8.68 × 10⁻² Gy/s Gross Tumor Volume (GTV) is achieved at a boron concentration of 140 μg/g, with minimal impact on surrounding tissues, and an optimal irradiation time of 18 minutes 22 seconds from the left-lateral direction.

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Published

2026-03-10

How to Cite

Rochimah, L., Pramono, S., Pratiwi, B. N., Sardjono, Y., Wijaya, G. S., Triatmoko, I. M., … Ismail, Z. (2026). Optimizing Boron Dose for Cervical Cancer Therapy Using BNCT and PHITS Simulations. Jurnal Teknologi Reaktor Nuklir Tri Dasa Mega, 27(1), 29–38. https://doi.org/10.55981/tdm.2025.7150

Issue

Vol. 27 No. 1 (2025): February 2025

Section

Articles