Optimization of Collimator Aperture Geometry for BNCT Kartini Research Reactor Using MCNPX
DOI:
https://doi.org/10.17146/tdm.2019.21.1.5049Keywords:
BNCT, Collimator, IAEA Parameters, MCNPX, Cylindrical shapeAbstract
Boron Neutron Capture Therapy (BNCT) is one of the promising cancer therapy modalities due to its selectivity which only kills the cancer cells and does not damage healthy cells around cancer. In principle, BNCT utilizes the high ionization properties of alpha (4He) and lithium (7Li) particles derived from the reaction between epithermal and boron-10 neutrons (10B + n → 7Li + 4He) in cells, where trace distance of alpha and lithium particles is equivalent with cell diameter. The neutron source used in BNCT can come from a reactor, as a condition for conducting BNCT therapy tests, there are five standard parameters that must be met for a neutron source to be used as a source, and the standards come from IAEA. This research is based on simulation using the MCNPX program which aims to optimize IAEA parameters that have been obtained in previous studies by changing the shape of the collimator geometry from cone shape to cylinder with variations diameter from 3, 5 and 10 cm and also the simulation divided into two schemes namely first moderator Al is placed in a position 9.5 cm behind the collimator and the second is the moderator Al is pressed into the base point of the aperture in the collimator. In this work, neutrons originated from Yogyakarta Kartini research reactor have the energy range in the continuous form. The results of the optimization on each scheme of the collimator are compared with the outputs that have been obtained in previous studies where the aperture of the collimator is in the cone shape. The most optimal output obtained from the results is a collimator with a diameter of 5 cm in the second scheme where the results of IAEA parameters that are produced (n/cm2 s) = 2.18E+8, / (Gy-cm2/n) = 6.69E-13, / (Gy-cm2/n) = 2.44E-13, = 4.03E-01, and J/ = 6.31E-01. These results can still be used for BNCT experiments but need a long irradiation time and when compared to previous studies, the output of the collimator with the diameter of 5 cm is more optimal.
References
Kasatov D., Koshkarev A., Kuznetsov A., Makarov A., Ostreinov Y., Shchudlo I., et al. The accelerator neutron source for boron neutron capture therapy. J. Phys. Conf. Ser. 2016. 769(1):012064.
https://doi.org/10.1088/1742-6596/769/1/012064
Mirzaei H., Sahebkar A., Salehi R., Nahand J., Karimi E., Jaafari M., et al. Boron neutron capture therapy: Moving toward targeted cancer therapy. J. Cancer Res. Ther. 2016. 12(2):520.
https://doi.org/10.4103/0973-1482.176167
Nedunchezhian K., Aswath N., Thiruppathy M., Thirugnanamurthy S. Boron Neutron Capture Therapy - A Literature Review. J. Clin. DIAGNOSTIC Res. 2016. 10(12):ZE01-ZE04.
https://doi.org/10.7860/JCDR/2016/19890.9024
Yura Y., Fujita Y. Boron neutron capture therapy as a novel modality of radiotherapy for oral cancer: Principle and antitumor effect. Oral Sci. Int. 2013. 10(1):9-14.
https://doi.org/10.1016/S1348-8643(12)00046-8
Molinari A.J., Thorp S.I., Portu A.M., Saint Martin G., Pozzi E.C.C., Heber E.M., et al. Assessing advantages of sequential boron neutron capture therapy (BNCT) in an oral cancer model with normalized blood vessels. Acta Oncol. (Madr). 2015. 54(1):99-106.
https://doi.org/10.3109/0284186X.2014.925140
Hermans R., Linnosmaa I., Shalowitz J. An economic model to assess the cost-benefit of BNCT. Appl. Radiat. Isot. 2015. 106:3-9.
https://doi.org/10.1016/j.apradiso.2015.08.021
Nakagawa Y., Yoshihara H., Kageji T., Matsuoka R., Nakagawa Y. Cost analysis of radiotherapy, carbon ion therapy, proton therapy and BNCT in Japan. Appl. Radiat. Isot. 2009. 67(7-8):S80-3.
https://doi.org/10.1016/j.apradiso.2009.03.055
Sauerwein W.A.G. Principles and Roots of Neutron Capture Therapy. in: Neutron Capture Therapy. Berlin, Heidelberg:Springer Berlin Heidelberg; 2012. pp. 1-16.
https://doi.org/10.1007/978-3-642-31334-9_1
Moss R.L. Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT). Appl. Radiat. Isot. 2014. 88:2-11.
https://doi.org/10.1016/j.apradiso.2013.11.109
Yoshioka M. Review of Accelerator-Based Boron Neutron Capture Therapy Machines. Proc. IPAC. 2016.:3171-5.
Sardjono Y., Widodo S., Irhas I., Tantawy H. A Design of Boron Neutron Capture Therapy for Cancer Treatment in Indonesia. Indones. J. Phys. Nucl. Appl. 2016. 1(1):1.
https://doi.org/10.24246/ijpna.v1i1.1-13
Warfi R., Harto A.W., Sardjono Y. Optimization of Neutron Collimator in The Thermal Column of Kartini Research Reactor for in vitro and in vivo Trials Facility of Boron Neutron Capture Therapy using MCNP-X Simulator. 2016. 1(10)
https://doi.org/10.24246/ijpna.v1i1.54-62
ARROZAQI M.I.M. PERANCANGAN KOLIMATOR DI BEAM PORT TEMBUS REAKTOR KARTINI UNTUK BORON NEUTRON CAPTURE THERAPY.Universitas Gadjah Mada; 2013.
Sardjono Y., Kusminarto K., Wusko I.U. The Optimization of Collimator Material and In Vivo Testing Dosimetry of Boron Neutron Capture Therapy (BNCT) on Radial Piercing Beam Port Kartini Nuclear Reactor by Monte Carlo N-Particle Extended (MCNPX) Simulation Method. Indones. J. Phys. Nucl. Appl. 2018. 3(1):29- 35.
https://doi.org/10.24246/ijpna.v3i1.29-35
Zailani R., Priambodo G., Sardjono Y. NEUTRON AND GAMMA SPECTRUM ANALYSIS OF KARTINI RESEARCH REACTOR FOR BORON NEUTRON CAPTURE THERAPY ( BNCT ) Boron Neutron Capture Therapy ( BNCT ) is a nuclear reaction-based cancer therapy in the form of interactions between neutrons with boron compounds . 2018. 22(3):59-68.
https://doi.org/10.17146/tdm.2018.20.2.4067
IAEA Current status of neutron capture therapy. Vienna, Austria:International Atomic Energy Agency: 2001