ANALISIS UNSUR MINERAL DAN KORELASINYA DALAM DARAH PENDERITA HIPERTENSI DAN NORMAL DENGAN TEKNIK AAN

Abstract

Mineral imbalance in the body may contribute to the development of hypertension. This paper has attempted to search differences of trace elements level in normal and hypertensive and the correlation between mineral elements in hypertension and normal blood. The research samples was composed of hypertensive patients (n= 34 ) aged 29-55 years and the normal controls (n = 52) aged 28-55 years. Analysis of trace elements was conducted using neutron activation analysis. To determine the significance of differences in levels of mineral elements in the blood hypertension and normal, t-testing of mean concentration and correlations between these elements is determined by the correlation coefficient. The results showed that there were differences in levels of elements in normal and hypertensive blood: <10% for the elements of K, Br, Zn, Rb and Cl; 10-30% for the elements Na, Se, Cr and Fe and difference > 30% for the elements Co , Cs and Cu. There are significant differences in Fe (P = 0.039) and Cu (P = 0.01) in the blood. There is a positive correlation between Fe and Cu in the blood hypertension (r = 0.218) and negative correlation in normal (r = -0.173). Between mineral elements there are positive correlation and there are also a negative correlation in hypertension and normal blood. So the possibility of changes in the blood levels of trace elements and inter-element correlation is a contributing factor in the pathogenesis of hypertension.