LEPRA PADA SISA RANGKA MANUSIA DARI LEWOLEBA: RELEVANSINYA TERHADAP SEJARAH PENGHUNIAN INDONESIA
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Abstract
Leprosy is a chronic, mildly communicable disease of man which primarily affects the skin, mucous membranes, peripheral nerves, eyes, bones and testes due to Mycobacterium leprae. Some researches show the evidence of leprosy spread worldwide in recent human history. Therefore, it is important to put leprosy’s case on the map to build broader knowledge, not only about the spread of leprosy, but also about human dispersal. The aim of the present study is to detect the M.leprae from ancient population in order to know its relevance to the peopling of Indonesia. Macroscopic method was performed based on Ortner method and Aufderheide and Rodriguez-Martin method to identify leprosy on the cranium of Lewoleba specimen (LLI/5), from Lembata Island, Indonesia. The antiquity of Lewoleba specimen is 2990+/-160BP. The results of the macroscopic method show that the specimen has suffered from leprosy in her lifetime. Some researchers concluded that emergence of leprosy related to human migration, in term of modern human dispersal, some researchers proved that the spread of leprosy worldwide consistent with the source of modern human (East Africa) and the spread of leprosy is also fit with the pattern of modern human dispersal. This fact provides an important clue how the M. leprae spread worldwide. Because the leprosy spread through human migration, this means also that leprosy could be infected the ancient people of Indonesia. This is because Indonesia was one of modern human migration's route
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References
Adi, I,G.G.H. 2006 Gen yang berkisah. National Geographic, edisi Indonesia, Maret: 48 – 51.
Adriaty, D., Wahyuni, R., Iswahyudi, Agusni, I., Izumi, S. 2010 TTC repeats variation of mycobacterium leprae isolates for analysis of leprosy endemic area in East Java, Indonesia. Indonesian Journal of Tropical and Infectious Disease. Vol. 1 (1): 38-41
Adriaty, D., Wahyuni, R., Iswahyudi, Aksono, B., Koesbardiati, T., Agusni, I., Izumi, S. 2011 DNA mycobacterium leprae pada tulang manusia purba dari Flores. Dipresentasikan pada KONAS XIII PERDOSKI di Manado.
Aufderheide, A.C. & Rodriguez-Martin, C. 1998 The Cambridge Encyclopedia of Human Paleopathology. Cambridge University Press.
Atmosudiro, S. 1994 Gerabah Prasejarah di Liang Bua, Melolo dan Lewoleba: Tinjauan teknologi dan fungsinya. Disertasi. Yogyakarta: Universitas Gadjah Mada. Tidak diterbitkan.
Cann, L.R., Stoneking, M., & Wilson, A.C. 1987 Mitochondrial DNA and Human Evolution. Nature 235: 31-36
Chhem, R.K & Brothwell, D.R. 2008 Paleoradiology. Berlin: Springer Verlag
Foley, R. & Lahr, M.M. 1997 Mode 3 technologies and the evolution of modern humans. Cambridge Archaeological Journal 7(1):3-36
Foster, P., & Matsumura, S. 2005 Did early humans go North or South? Science Vol. 308: 965-966.
Glinka, J. 1978 Gestalt und Herkunft: Beitrag zur Anthropologischen Gliderung Indonesiens. Studia Instituti Anthropos Vol. 35. Bonn:Verlag des Anthropos-Instituts
Gwen, R., Tripathy, M., Misra, V.N., Mohanty, R.K., Shinde, V.S., Gray, K.M., Shug, M.D. 2009 Ancient Skeletal Evidence for Leprosy in India (2000 BC). PLoS ONE Vol. 4(5): 1-8
Haas, C.J., Zink, A., Palfi, G., Szeimies, U., Nerlich, A.G. 2000 Detection of Leprosy in ancient human skeletal remains by molecular identification of Mycobacterium leprae. Am.J.Clin Pathol 114:428-436.
Jacob, T. 1967 Some problems pertaining to the racial history of the Indonesian region. Utrecht: Drukkerij Nerlandia
Koesbardiati, T. 2000 On the relevance of the regional continuity features of the face in East Asia. Disertasi. Universitaet Hamburg. Tidak dipublikasikan.
Koesbardiati, T., & Suriyanto, R. 2007a Australomelanesoid in Indonesia: a Swinging-like movement. J.Anat Ind. Vol. 2 (1): 23-28
Koesbardiati, T., & Suriyanto, R. 2007b Menelusuri jejak populasi morfologi pangur gigi-geligi: kajian pendahuluan atas sampel gigi-geligi dari beberapa situs purbakala di Jawa, Bali dan Nusa Tenggara Timur. Humaniora 19: 33 – 42.
Lie, G.L. 1964 Beberapa Hasil Paleoanthropologis dari Penemuan-Penemuan di Pantai Lewoleba, P. Lomblen. Madjalah Research Kedokteran Surabaja. 3: 121-137
Lie, G.L. 1965 Palaeonthropological results of the excavation at the coast of Lewoleba (Isle Lomblen). Anthropos 60:610-624
Louisiana Office of Public Health. 2004 Hansen Disease.
Macaulay, V., Hill, C., Achilli, A., Rengo., C., Clarke, D., Meehan, W., Blackburn, J., Semino, O., Scozzan, R., Cruciani, F., Taha, A.,
Shaari, N.K., Raja, J.M., Ismail, Z.Z., Goodwin, W., Bulbeck, D., Bandelt, H.J., Oppenheimer, S., Toroni, A., Richards, M. 2005 Single, rapid coastal settlement of Asia revealed by analysis of
complete mitochondrial genomes. Science Vol. 308:1034-1036
Matsuoka, M., Zhang, L., Budiawan, T., Saeki, K., Izumi, S. 2004 Genotyping of mycrobacterium leprae on the basis of the polymorphism of TTC repeats for analysis of leprosy transmission. Journal of Clinical Microbiology Vol. 42(2): 741-745
Mellars, P. 2006 Going East: New Genetic and Archaeological Perspectives on the Modern Human Colonization of Euroasia. Science Vol. 313:796-800.
Monot, M., Honore N., Garnier, T., Araoz, R., Coppee, Y-J., Celine, L., Sow, S., Spencer, J.S., Truman, R.W., Williams, D.L., Gelber, R., Virmond, M., Flageul, B., Cho, S.N., Ji. B., Oaniz-Mondolfi, A., Convit, J., Young, S., Fine, P.E., Rasolofo, V., Brennan, J., Cole, S.T. 2005 On the origin of leprosy. Science Vol. 308:1040-1042.
Monot, M., Honore, N., Garnier, T., Zidane, N., Sherafi, D., PAniz-Mondolfi, A., Matsuoka, M., Taylor, M.G., Donoghue, H.D., Bouwman, A., Mays, S., Watson, C., Lockwood, D., Khamesipour, A., Dowlati, Y., Jianping, S., Rea, T.H., Vera-Cabera, L., Stefani, M.M., Banu, S., MacDonald, M., Sapkota, B.R., Spencer, J., Thomas, Je., Harsman, K., Singh, P., Buso, P., Gattiker, A., Rougemont, J., Brennan, P., Cole, S.T. 2009 Comparative Genomic and phylogeographyc analysis of Mycobacterium Leprae. Nature Genetics 41, 1282-1289.
Ortner, D. J. 2003 Identification of Pathological Conditions in Human Skeletal Remains. Amsterdam: Academic Press.
Stringer, C. 1992 Replacement, continuity and the origin of Homo sapiens. Continuity or replacement: controversies in Homo sapiens (Brauer & Smith, eds.). Rotterdam: A.A. Balkema
Stoneking, M. & Cann, R. 1989 African origin of human mitochondrial DNA. The human revolution: behavioral and biological perspectives on the origins of modern humans (Mellars & Stringer, Eds). Edinburg University Press.
Suzuki, K., Takigawa, W., Tanigawa, K., Nakamura, K., Ishido, Y., Kawashima, A., Wu, H., Akama, T., Sue, M., Yoshihara, A., Mon, S., Ishii, N. 2010 Detection of Mycobatrium leprae DNA from archaeological skeletal remains in Japan using whole genome
amplification and polymerase chain reaction. PLos ONE Vol. 5(8):1-8
Tayles, N. & Buckley, H.R., 2004 Leprosy and Tuberculosis in Iron Age Southeast Asia? Am.J.Phys. Anthropol. 125:239-256
Taylor, M.G., Widison, S., Brown, I.N., Young, D., Molleson, T. 2002 A Medieval case of lepromatous leprosy from 13-14th century Orkney, Scottland. Journal of Archaeological Science Vol 27(12): 1133-1138
Thangaraj, K., Chaubey, G., Kivisild, T., Reddy, A.G., Singh, V.K., Rasalkar, A.A., Singh, L. 2005 Reconstructing the origin of Andaman Islanders. Science Vol. 308: 996
