ISOLATION AND IDENTIFICATION OF APIGENIN, A FLAVONOID COMPOUND FROM MACARANGA HYPOLEUCA (REICHB.F. & ZOLL.)

Authors

  • Sitti Aisya Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research and Innovation Agency of Indonesia (BRIN)
  • Megawati Megawati Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research and Innovation Agency of Indonesia (BRIN)
  • Novita Ariani Research Center for Chemistry, Research and Innovation Agency of Indonesia (BRIN)
  • Sukirno Sukirno Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research and Innovation Agency of Indonesia (BRIN)
  • Minarti Minarti Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research and Innovation Agency of Indonesia (BRIN)
  • Hendris Hendarsyah Kurniawan Research Center for Chemistry, Research and Innovation Agency of Indonesia (BRIN)
  • Arief Hidayat Research Center for Biosystematic and Evolution, Research and Innovation Agency of Indonesia (BRIN)
  • Medi Hendra Department of Biology, Faculty of Mathematic and Natural Sciences, Mulawarman University
  • Gian Primahana Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research and Innovation Agency of Indonesia (BRIN)
  • Akhmad Darmawan Research Center for Pharmaceutical Ingredients and Traditional Medicine, Research and Innovation Agency of Indonesia (BRIN)

DOI:

https://doi.org/10.55981/beritabiologi.2024.3242

Keywords:

Macaranga hypoleuca (Reichb.f. & Zoll.), flavonoid, flavone, apigenin

Abstract

The study on Macarang hypolueca (Reichb.f. & Zoll.), which was collected from secondary forests around Samarinda City, East Kalimantan, involved phytochemical investigations that led to the isolation of a flavone type compound of flavonoid from the ethyl acetate fraction. To separate the compounds, silica gel column chromatography was utilized with a gradient solvent system of n-hexane and ethyl acetate, along with the addition of 5%. Infrared analysis (FTIR), mass spectrum (LC-ESI-MS), and nuclear magnetic resonance (1D- and 2D-NMR) were used to identify and elucidate the structure. Based on spectroscopic data and comparison with appropriate references, the isolated compound was identified as apigenin

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Published

2024-04-16