BIODIVERSITY AND ANTIBACTERIAL ACTIVITIES OF ENDOPHYTIC FUNGI ASSOCIATED WITH UNCARIA GAMBIER (HUNTER) ROXB. VAR. UDANG FROM JASINGA, BOGOR, INDONESIA

Authors

  • Kartika Dyah Palupi Research Center Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia,16911
  • Andi Saptaji Kamal Research Center Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia,16911
  • Lina Marlina Research Center Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia,16911
  • Lukman Hafid Research Center Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia,16911
  • Evana Research Center Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia,16911
  • Elsera Br Tarigan Research Center Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia,16911
  • Marlin Megalestin Raunsai
  • Muhammad Ilyas Research Center for Biosystematic and Evolution, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia, 16911
  • Atit Kanti Research Center for Biosystematic and Evolution, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia, 16911
  • Andria Agusta Research Center Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Jalan Raya Jakarta-Bogor Km. 46, Bogor, Indonesia,16911

DOI:

https://doi.org/10.55981/beritabiologi.2023.713

Abstract

Endophytic fungi living in medicinal plant tissues are potential bioactive metabolite sources for drug discovery and development. However, the research regarding endophytic fungi associated with Indonesian medicinal plants is still limited. This study aimed to explore the biodiversity of endophytic fungi associated with the medicinal plant Uncaria gambir (Hunter) Roxb. var. udang and their antibacterial activities. Twenty-seven endophytic filamentous fungi were isolated from the surface-sterilized leaves, stems, and roots of Uncaria gambir (Hunter) Roxb. var. udang collected in Jasinga, Bogor, West Java, Indonesia. The observation based on the morphological characters both macroscopically and microscopically, as well as chemical profiling using thin layer chromatography (TLC), revealed that some of the isolated endophytic fungi were identical. Overall, the isolated endophytic fungi consist of six Coelomycetes, three Dematiaceae, four Pestalotiopsis sp., two Penicillium sp., one Aspergillus terreus, and two fungi were unidentified. Antibacterial activities of the ethyl acetate extract from the isolated endophytic fungi associated with Uncaria gambir (Hunter) Roxb. var. udang were observed against E. coli, B. subtilis, S. aureus, and M. luteus. Twelve types of isolated endophytic fungi from Uncaria gambir (Hunter) Roxb. var. udang exhibited antibacterial activities.

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Published

2023-10-02