AKTIFITAS ANTIOKSIDAN DAN ANTIKOAGULASI RESIN JERNANG
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Abstract
Dragon's blood is essentially a red-colored resin secreted by the fruits of rattan species. The dragon's blood originated from Indonesia which becomes widespread in international market is indigenous from Daemonorops spp. The dragon's blood has been popularly used as traditional medicines. To confirm such dragon's blood efficacy, an assesment was already conducted regarding the phytochemical screening, antioxidant activity, and anticoagulant activity indicatively afforded by the dragon's blood resin produced by three rattan species, ie. Daemonorops longipes Mart, Daemonorops draco BL, and Daemonorops melanochaetes BL. Phytochemical screening aimed to identify the kinds of chemical compounds inside the dragon's blood resin; antiæcidant tests used DPPH (2,2-diphenyl-1-picrylhydrazyl); and anticoagulation tests proceed in-vitro using rabbit blood.
Results revealed that the dragon's blood from those three species, exctracted using polar (methanol) and semi-polar (ethyl acetate) solvents, contained chemical compounds which are already renowed for medicinal efficacy and potent antinccidant, e.g. flavonoids, triterpenoids, and tannin. The greatest antioccidant potency was imparted by dragon's blood from Daemonorops longipes Mart, as indicated by its lowest IC value (71.89U+3,89 mgl.). The ethyl acetate dragon's blood extract, rather than promoting anticoagulat action on the rabbit-blood, in fact induced the blood coagulation, whereby the extract from Daemonorops longipes Mart performed the most effectively (shortest in coagulation time).
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References
Achmadi, S.S. 1992. Kimia Kayu. Departemen Pendidikan Dan Kebudayaan. Dirjen Pendidikan Tinggi. Pusat Antar Universitas Ilmu Hayat, Institut Pertanian Bogor. Bogor.
Anung, E.T. 2006. Melanin Biosynthesis Inhibitory Compounds from Arthocarpus heterophyllus. (Dissertation). Kyushu University. Japan.
Barlow, S.M. 1990. Toxicological aspect of antioxidants used as food additives. Elsevier. London.
Blouis, M.S. 1958. Antioxidant determinations by the use of a stable free radical. Nature 181:1199-1200.
Chung, K.T.; T. Y. Wong; C. I. Wei; Y. W. Huang and Y. Lin. 1998. Tannins and human health. Critical Review in Food Science and Nutrition, 38(6): 421-464
Cook, N.C. and S. Samman. 1996. Flavonoids-Chemestry, metabolism, cardioprotective effects, and dietary sources. Nutritional Biochemestry 7: 66-76
Coppen, J.J.W. 1995. Gum, resins, and latexes of plant origin. Non Wood Forest Products. No.6. FAO, Roma.
Dzubak, P.; M. Hajduch; D. Vydra; A. Hustova; M. Kvasnica; D. Biedermann; L. Markova; M. Urban and J. Sarek. 2006. Pharmacological activities of natural triterpenoids and their therapeutic implications. Nat.Prod.Rep. 23: 394-411
Gupta, D.; B. Bleakley and R. K. Gupta. 2008. Dragon’s blood : Botany, chemistry and therapeutic uses. Journal of Ethnopharmacology, 115(3) : 361-380
Gupta, D. and R.K. Gupta. 2011. Bioprotective properties of Dragon’s blood resin : In vitro evaluation of antioxidant activity and antimicrobial activity. Complementary and Alternative Medicine 11: 1-9
Harborne, J.B. 1987. Metode Fitokimia : Penuntun cara modern menganalisis tumbuhan. Penerbit ITB Bandung. (terjemahan)
Hashimoto, K.; S. Nakahara; T. Inoue; Y. Sumida; M. Takahashi and Y. Masada. 1985. A New chromone from agarwood and pyrolysis products of chromone derivatives. Chem. Pharm. Bull. 33(11): 5088-5091
Koffour, G. A. and P. Amoateng. 2011. Antioxidant and anticoagulant properties of Phyllanthus fraternus GL Webster (Family : Euphorbiaceae). Journal of Pharmacology and Toxycology 6 (7) : 624-636.
Mattjik, A. dan I. Sumertajaya. 2002. Perancangan Percobaan dengan Aplikasi SAS dan MINITAB. Jilid I. IPB PRESS Bogor.
Miura, T.; T. Nishinaka; T. Terada and K. Yonezawa. 2010. Relationship between aging and dosage of warfarin : The current status of warfarin outpatients in a department of cardiovascular medicine. Journal of Cardiology 53 : 355-360
Molyneux, P. 2004. The use of stable free radical diphenylpicrylhydrazyl (DPPH) for estimazing antioxidant activity. Songklanakarin J Sci Technol 26:211-219
Nicholl, I.A.; B.C.G. Karlsson.; A.M. Rosengren and H. Henschel. 2010. Warfarin : an environment-dependent switchable molecular probe. Journal of Molecular Recognition 23 : 604-608
Niranjan, M.H. and M.S. Sudarshana. 2010. Preliminary phytochemical studies of Lagerstroemia indica Linn. Journal of Pharmacy 3(2) : 216-218
Pearson, J. and D. V. Prendergast. 2001. Collection corner : Daemonorops, Dracaena and other Dragon’s Blood. Economic Botany, 55 : 474-477
Pearson, J. 2002. Dragon’s Blood. Horticulturist 11(2) : 10-12
Silva, B.M.; R.P. Santos; L.S. Mendes; P.G. Pinho; P. Valentao; P.B. Andrade; J.A. Pereira and M. Carvalho. 2010. Dracaena draco L. fruit : Phytochemical and antioxidant activity assessment. Food Research International, doi:10.1016/j.foodrres.2010.09.031
Sumadiwangsa, S. 1973. Klasifikasi dan sifat beberapa hasil hutan bukan kayu. Direktorat Jenderal Kehutanan, Departemen Pertanian. Bogor. Laporan No. 28.
Sunarni T. 2005. Aktivitas antioksidan penangkap radikal bebas beberapa kecambah dari biji tanaman familia Papilionaceae. J. Farm Indonesia 2:53-61
Tiwari, P.; B. Kumar; M. Kaur; G. Kaur and H. Kaur. 2011. Phytochemical screening and Extraction : A Review. Internationale Pharmaceutica Sciencia 1(1) : 98-106
Yi, T.; H.B. Chen.; Z.Z. Zhao.; Z.L. Yu and Z.H. Jiang. 2011. Comparison of the chemical profile and anti-platelet aggregation effects of two ”Dragon’s Blood” drugs used in traditional Chinese medicine. Journal of Ethnopharmacology 133 : 796-802
Yi, T.; Y. Tang; J. Zhang; Z. Zhao; Z. Yang and H. Chen. 2012. Characterization and determination of six flavonoids in the ethnomedicine ”Dragon’s Blood” by UPLC-PAD-MS. Chemestry Central Journal 6 : 1-7
Xu, Z. and L.R. Howard. 2012. Analysis of Antioxidant-Rich Phytochemicals. A John Wiley & Sons, Ltd.
