STANDARDISASI EKSTRAK KULIT KAYU BANGKAL (Nauclea subdita (Korth.) Steud.) SEBAGAI BAHAN BAKU SEDIAAN KOSMETIKA
Main Article Content
Abstract
Bangkal bark is used as a cosmetic raw material by residents of South Kalimantan and has been proven to have
good pharmacological activity as an antibacterial and free radical scavenger. Phenolic is one of the compounds found in
bangkal plants. It can be used as markers to standardize and determine the extract stability that will be developed as
effective and safe materials. This study aims to observe antibacterial and free radical scavenging active materials that
stable and safe from bangkal bark for application in pharmaceutical and cosmetic products. The extraction process used
a percolation method with distilled water, then standardized according to the PPOMN reference and tested for stability
using the accelerated stability method with a total phenolic marker. The extract was tested for free radical scavenging
activity against DPPH, and antibacterial activity was tested against Propionibacterium acne and Staphylococcus
aureus by disc paper diffusion method. The results showed that bangkal extract was stable during testing at 40°C and
75% RH for 12 weeks. Total phenolic range between 7.18 ± 0.31−7.43 ± 0.21 µg/mg. Antiradical scavenging
activity showed a value of IC50 of 3,158.3 μg/ml, and antibacterial activity testing showed MIC value of the angkal
extract against P. acne and S. aureus at ≥ 100,000 ppm and 100,000 ppm. Extract standardization results showed
that the bangkal wood extract met the quality standard and could be used as a raw material for cosmetic materials.
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